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Different Mechanisms of Apoptosis by Influenza A and B Virus
Santos, L.A.; Solá, S.; Correia, V.; Rodrigues, C.M.P.; Rebelo-de-Andrade, H.Background and Aims: The ability of Influenza A (infA) viruses to counteract and manipulate the host response to infection is well acknowledged. In addition, the activation of the PI3K/Akt survival pathway by the infA NS1 protein has been described as one of the strategies to delay the apoptotic response of the infected cell. As influenza B (infB) viruses differ genetically and phenotypically from infA viruses,...
Selective pressure acting on influenza virus neuraminidase protein and relation...
Correia, V.; Santos, L.A.; Giria, M.; Rebelo-de-Andrade, H.Neuraminidase (NA) protein of influenza viruses has the particularity of being under antibody and antiviral drug selective pressure, as it is one of the main surface antigens and the target of neuraminidase inhibitors(NAIs). The aim of this study is to investigate the selective pressure(SP) acting on the NA of seasonal and pandemic influenza viruses. It comprises two objectives: (a)to evaluate the contribution ...
Evaluation and Characterization of Influenza Antiviral Drug Resistance in Portu...
Correia, V.; Santos, L.A.; Giria, M.; Rebelo-de-Andrade, H.In 2007 started to be carried out for the first time in Portugal a study focused on influenza antiviral drug resistance. Three main objectives were established:(1)to determine the antiviral profile of influenza viruses to oseltamivir, zanamivir and amantadine;(2)to determine and monitor the baseline level of susceptibility along winter seasons and for each influenza sub(type);(3)to analyse and characterize the ...
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caus...
Rebelo-de-Andrade, H; Pereira, C; Gíria, M; Prudêncio, E; Brito, MJ; Calé, E; Taveira, NHuman adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and vir...
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