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Modulation of Acute Myeloide Leukaemis (AML) metabolism by the vascular Endothe...

Several studies have highlighted cancer metabolism as a suitable target to develop new therapies. This thesis aimed at determining the role of lactate metabolism in AML, both VEGF dependent and independent, by developing an in vitro study (pro-myelocytic-HL60 and erithroblastic-HEL). We observed that HL60 and HEL have different metabolic profiles when exposed to lactate and/or VEGF. NMR analysis showed that HL6...