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Calciphylaxis: a Literature Review Based in Two Case Reports
Mendes, M; Ferreira, AC; Ferreira, A; Nolasco, FCalciphylaxis is a rare and devastating obliterative vasculopathy, leading to ischemia and subcutaneous necrosis. In most cases it affects patients with renal disease and is associated with high morbidity and mortality. We present two case reports followed recently in our department, and a literature review on this topic. Case one refers to an 80 -year -old Caucasian woman with chronic kidney disease stage 5 an...
Transplant glomerulopathy: clinico-pathologic features
Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, FTransplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...
Transplant Glomerulopathy: Clinico-Pathologic Features
Silva, C; Cotovio, P; Marques, M; Afonso, N; Sancho, MR; Carvalho, F; Trindade, H; Carreira, A; Campos, M; Nolasco, FTransplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year per...
ABO-Incompatible Liver Transplantation in Acute Liver Failure: A Single Portugu...
Mendes, M; Ferreira, AC; Ferreira, A; Remédio, F; Aires, I; Cordeiro, A; Mascarenhas, A; Martins, A; Pereira, P; Glória, H; Perdigoto, R; Veloso, JINTRODUCTION: ABO-incompatible liver transplantation (ABOi LT) is considered to be a rescue option in emergency transplantation. Herein, we have reported our experience with ABOi LT including long-term survival and major complications in these situations. PATIENT AND METHODS: ABOi LT was performed in cases of severe hepatic failure with imminent death. The standard immunosuppression consisted of basiliximab, c...
Patologia Dermatológica em Doentes Transplantados Hepáticos e Renais Referencia...
Fernandes, S; Carrelha, AS; Marques Pinto, G; Nolasco, F; Barroso, E; Cardoso, JIntrodução: Foram descritas várias doenças cutâneas em doentes transplantados, em relação com a terapêutica imunossupressora instituída. Pretendemos caracterizar o espectro clínico das patologias dermatológicas e comparar os diagnósticos entre os doentes transplantados hepáticos e os doentes transplantados renais. Material e Métodos: Estudo descritivo e retrospectivo através da consulta de processos clínicos de...
Familial Amyloidotic Polineuropathy and Systemic Lupus
Ferreira, AC; Carvalho, F; Nolasco, FFamilial amyloidotic polineuropathy is a genetic disorder, leading to systemic amyloid deposits, manifested as sensory-motor and autonomic neuropathy. In the Portuguese classical form, the disease is evident at a young age, and causes death if no specific treatment is received. Variability in penetrance, age of onset and clinical course has been published; environmental and genetic factors are believed to contr...
Orthotopic Liver Transplantation in Familial Amyloidotic Polyneuropathy Is Asso...
Ferreira, AC; Nolasco, F; Sampaio, S; Baptista, A; Pessegueiro, P; Monteiro, E; Barroso, EOrthotopic liver transplantation has become the treatment of choice for familial amyloidotic polyneuropathy. The aims of this study were to evaluate the renal complications post orthotopic liver transplantation in familial amyloidotic polyneuropathy and their impact. We retrospectively studied 185 recipients who underwent 217 orthotopic liver transplants. Mean age 36.8±9.5 years, 59% males, 14.3% with renal dys...
C4d Detection in Renal Allograft Biopsies: Immunohistochemistry vs. Immunofluor...
Santos, A; Viana, H; Galvão, MJ; Carvalho, F; Nolasco, FIntroduction. Peritubular capillary complement 4d staining is one of the criteria for the diagnosis of antibody-mediated rejection, and research into this is essential to kidney allograft evaluation. The immunofluorescence technique applied to frozen sections is the present gold-standard method for complement 4d staining and is used routinely in our laboratory. The immunohistochemistry technique applied to para...
Optimization of the Tartrate-Resistant Acid Phosphatase Detection by Histochemi...
Galvão, MJ; Santos, AR; Ribeiro, MD; Ferreira, A; Nolasco, FAccording to the new KDIGO (Kidney Disease Improving Global Outcomes) guidelines, the term of renal osteodystrophy, should be used exclusively in reference to the invasive diagnosis of bone abnormalities. Due to the low sensitivity and specificity of biochemical serum markers of bone remodelling,the performance of bone biopsies is highly stimulated in dialysis patients and after kidney transplantation. The tart...
Treatment of Hepatitis C Virus Infection in Kidney Transplant Recipients: Case ...
Caeiro, F; Baptista, V; Rodrigues, N; Carvalho, D; Aires, I; Remédio, F; Nolasco, FChronic hepatitis C virus (HCV) infection exists in a large proportion of patients undergoing renal transplantation. Nowadays it is not considered to be an absolute contraindication to transplantation; however, it is associated with an increased risk for the patient and accounts for a shorter half-life of the renal allograft. We present three transplant recipients who displayed serious hepatic dysfunction after...
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