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The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrup...
Granja, Sara Costa; Santos, Filipa Morais; Gonçalves, Vera M.; Ferreira, Manuel Viana; Nogueira, Rosete; Silva, Cristina Nogueira; Pinto, Jorge CorreiaBACKGROUND/AIMS: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids have an important role in cell metabolism and their rapid transport across the plasma membrane is crucial for the maintenance of intracellular pH homeostasis. This...
Lactate-induced il-8 pathway in endothelial cells-letter
Pinheiro, Céline; Longatto Filho, Adhemar; Nogueira, Rosete; Schmitt, Fernando C.; Baltazar, FátimaVegran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT...
Review of breast pathology: diagnosed by fine needle aspiration and correlation...
Furtado, Antónia; Nogueira, Rosete; Tente, David; Couceiro, AntónioThe 980 exams concerning breast pathology performed in an 18-month period, including 626 fine needle aspiration biopsies, were reviewed. A diagnosis was made in 78.2% of fine needle aspiration biopsies, and in the remaining 21.8% they were considered insufficient for diagnosis. It was possible to establish a correlation with histological findings in 109 cases. There was accordance in 87.2% of the cases, a discr...
Melanoma of the small bowel: primary or metastatic? a clinical case
Póvoa, Antonia A.; Interna Complementar de Cirurgia Geral – Serviço de Cirurgia Geral do Centro Hospitalar de Vila Nova de Gaia, PortugalMalignant melanoma often originated from melanocytes can occur wherever these cells are present. Most common locations are the skin, retina, anus and under the nail. Although rare, primary gastrointestinal tract melanoma has been reported, mostly from the oesophagus and anorectal region. In the small bowel represents 5% of primary neoplasms. We report a case of a 70 year old man, who presented with abdominal pa...
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