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Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium...
Carvalho, Filomena A.; Carneiro, Fabiana A.; Martins, Ivo C.; Assunção-Miranda, Iranaia; Faustino, André F.; Pereira, Renata M.; Bozza, Patricia T.Copyright © 2012, American Society for Microbiology. All Rights Reserved. ; Dengue virus (DENV) affects millions of people, causing more than 20,000 deaths annually. No effective treatment for the disease caused by DENV infection is currently available, partially due to the lack of knowledge on the basic aspects of the viral life cycle, including the molecular basis of the interaction between viral components ...
Revisiting steroid treatment for septic shock: molecular actions and clinical e...
Japiassú,André M; Salluh,Jorge IF; Bozza,Patrícia T; Bozza,Fernando A; Castro-Faria-Neto,Hugo CCorticosteroids are widely used to treat a diversity of pathological conditions including allergic, autoimmune and some infectious diseases. These drugs have complex mechanisms of action involving both genomic and non-genomic mechanisms and interfere with different signal transduction pathways in the cell. The use of corticosteroids to treat critically ill patients with acute respiratory distress syndrome and s...
Analgesic and anti-inflammatory activity of the aqueous extract of Rheedia long...
Frutuoso,Valber da Silva; Monteiro,Márcia Magalhães; Amendoeira,Fábio Coelho; Almeida,Andressa Luiza Figueiredo; Nascimento,Diogo Dibo doRheedia longifolia Planch et Triana belongs to the Clusiaceae family. This plant is widely distributed in Brazil, but its chemical and pharmacological properties have not yet been studied. We report here that leaves aqueous extract of R. longifolia (LAE) shows analgesic and anti-inflammatory effects. Oral or intraperitoneal administration of this extract dose-dependently inhibited the abdominal constrictions in...
Mechanisms of leukocyte lipid body formation and function in inflammation
Bozza,Patrícia T; Bandeira-Melo,ChristianneAn area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and phosphatases) and pools of lipid precursors. The compartmentalization of signaling components within discrete and dynamic sites in the cell is critical for specificity a...
Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers...
Bozza,Fernando A; Bozza,Patrícia T; Castro Faria Neto,Hugo CSepsis is a major challenge in medicine. It is a common and frequently fatal infectious condition. The incidence continues to increase, with unacceptably high mortality rates, despite the use of specific antibiotics, aggressive operative intervention, nutritional support, and anti-inflammatory therapies. Typically, septic patients exhibit a high degree of heterogeneity due to variables such as age, weight, gend...
A role for lymphocytes and cytokines on the eosinophil migration induced by LPS
Castro-Faria-Neto,Hugo C; Penido,Carmen M; Larangeira,Andréa P; Silva,Adriana R; Bozza,Patrícia TIn the present work we review the existing evidence for a LPS-induced cytokine-mediated eosinophil accumulation in a model of acute inflammation. Intrathoracic administration of LPS into rodents (mice, rats or guinea pigs) induces a significant increase in the number of eosinophils recovered from the pleural fluid 24 hr later. This phenomenon is preceded by a neutrophil influx and accompanied by lymphocyte and ...
Mechanisms of formation and function of eosinophil lipid bodies: inducible intr...
Bozza,Patricia T; Yu,Wengui; Weller,Peter FLipid bodies, inducible lipid-rich cytoplasmic inclusions, are characteristically abundant in cells associated with inflammation, including eosinophils. Here we reviewed the formation and function of lipid bodies in human eosinophils. We now have evidence that the formation of lipid bodies is not attributable to adverse mechanisms, but is centrally mediated by specific signal transduction pathways. Arachidonic ...
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