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In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene suc...

In tissue engineering, the evaluation of the host response to the biomaterial implantation must be assessed to determine the extent of the inflammatory reaction. We studied the degradation of poly(butylene succinate) and chitosan in vitro using lipase and lysozyme enzymes, respectively. The subcutaneous implantation of the scaffolds was performed to assess tissue response. The type of inflammatory cells present...

Sífilis congénita – caso clínico

Indirect co-cultures of stem cells with chondrocytes for cartilage tissue engin...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Mesenchymal Stem Cells (MSCs) have been recognized for their ability to differentiate into cells of different tissues such as bone, cartilage or adipose tissue, and therefore might be of interest for potential therapeutic strategies. These cells are induced to differentiate by growth factors supplementation in cult...

Immobilization of bioactive factor-loaded liposomes at the surface of electrosp...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The ability to manipulate and control the surface properties is of crucial importance in the designing of scaffolds for Tissue Engineering (TE) and Regenerative Medicine. Electrospun nanofibers (NFM), due to their morphology and fibrous structure have received much attention as potential biomedical devices, TE scaf...

Tissue engineering as a remarkable tool for cartilage repair

Articular cartilage is a very specialized tissue with outstanding load-bearing capacity. It consists mainly of a dense extracellular matrix (ECM) with chondrocytes embedded on it. Cartilage has very low capacity of self-repair and regeneration after traumatic, degenerative or inflammatory injury. Current available surgical treatments for cartilage repair present several drawbacks, such as possible implant rejec...

Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...

It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...

Chitosan – poly(butylene succinate) scaffolds and human bone marrow stromal cel...

Tissue engineering sustains the need of a three-dimensional (3D) scaffold to promote the regeneration of tissues in volume. Usually, scaffolds are seeded with an adequate cell population, allowing their growth and maturation upon implantation in vivo. Previous studies obtained by our group evidenced significant growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) w...

Osteogenic differentiation of two distinct subpopulations of human adipose-deri...

The first stem cells considered for the reconstruction of bone were bone marrow mesenchymal stem cells (BMSCs). Subsequently, cells with similar marker expression panel and differentiation potential were found in new sources of cells, such as adipose tissue. This source of stem cells has a promising future in tissue-engineering applications, considering the abundance of this tissue in the human body, the easy h...

Chondroitin sulfate immobilization at the surface of electrospun nanofiber mesh...

Aiming at improving the biocompatibility of biomaterial scaffolds, surface modification presents a way to preserve their mechanical properties and to improve the surface bioactivity. In this work, chondroitin sulfate (CS) was immobilized at the surface of electrospun poly(caprolactone) nanofiber meshes (PCL NFMs). The immobilization was performed with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydro...

Induction of human mesenchymal stem cells osteogenesis by bioactive agent-relea...

Stem cell therapy is a rapidly evolving area of research in regenerative medicine. Mesenchymal stem cells (MSCs) have received considerable attention by the scientific community because of their potential of expansion and the ability to differentiate into various mesodermal tissues. Liposomes are well-established non-viral carrier systems, presenting significant advantages over other nanoparticle-based drug del...