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Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasom...

Francisco, Vera; Costa, Gustavo; Figueirinha, Artur; Marques, Carla; Pereira, Paulo; Neves, Bruno Miguel; Lopes, Maria Celeste; García-Rodríguez, Carmen

Ethnopharmacological relevance Cymbopogon citratus (DC.) Stapf leaves infusion is used in traditional medicine for the treatment of inflammatory conditions, however little is known about their bioactive compounds. Aim of the study Investigate the compounds responsible for anti-inflammatory potential of Cymbopogon citratus (Cy) on cytokines production induced by lipopolysaccharide (LPS) in human and mouse macro...


Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View

Neves, Bruno Miguel; Lopes, Maria Celeste; Cruz, Maria Teresa

An effective host defense against pathogens requires appropriate recognition of the invading microorganism by immune cells, conducing to an inflammatory process that involves recruitment of leukocytes to the site of infection, activation of antimicrobial effector mechanisms and induction of an adaptive immune response that ultimately will promote the clearance of infection. All these events require the coordina...


Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guid...

Francisco, Vera; Figueirinha, Artur; Neves, Bruno Miguel; García-Rodríguez, Carmen; Lopes, Maria Celeste; Cruz, Maria Teresa; Batista, Maria Teresa

Ethnopharmacological relevance Aqueous extracts of Cymbopogon citratus (Cy) leaves are used in traditional medicine for the treatment of inflammatory conditions, however, little is known about their mechanism of action. Aim of the study The aim of this study is to explore the anti-inflammatory properties of Cymbopogon citratus leaves and their polyphenol-rich fractions (PFs), as well its mechanism of action i...


Influência do molibdénio na acumulação de nitratos nas folhas de alface (Lactuc...

Neves, Bruno Miguel Pedroso

Mestrado em Engenharia Agronómica - Instituto Superior de Agronomia ; In this study four field experiments and one pot experiment were conducted with the aim of studying the decrease of nitrate accumulation in the lettuce leaves. To achieve this objective the following issues were addressed: effects of molybdenum applied either in fertirrigation and/or foliar fertilization; the influence of different lettuce v...

Data: 2011   |   Origem: Repositório da UTL

A percepção do termo desertificação na comunicação social, na política e na soc...

Neves, Bruno Miguel Almeida

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Gestão do Território, área de especialização em Ambiente e Recursos Naturais ; A Desertificação é considerada actualmente um dos mais graves problemas ambientais à escala global, com implicações económicas, sociais e ambientais. Está também associada à perda de biodiversidade e às mudanças climáticas. Portugal, ...

Data: 2010   |   Origem: Repositório Institucional da UNL

Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers an...

Neves, Bruno Miguel; Cruz, Maria Teresa; Francisco, Vera; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste

The development of non-animal methods for skin sensitization testing is an urgent challenge. Some of the most promising in vitro approaches are based on the analysis of phenotypical and functional modifications induced by sensitizers in dendritic cell models. In this work, we evaluated, for the first time, a fetal skin-derived dendritic cell line (FSDC) as a model to discriminate between sensitizers and irritan...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia