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Starch-based microparticles as carriers for the delivery of platelet-derived gr...

Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.

We have previously shown that starch-based microparticles are bioactive [1], serve as substrates for the culture of osteoblast-like cells [2], and are suitable for controlled release applications [3]. In this way, we postulate that if we combine these different properties we could generate hybrid constructs with enhanced properties. Hence, we describe herein the encapsulation and release of Platelet-Derived Gro...


Starch-based microparticles as vehicles for the delivery of active platelet-der...

Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.

In a previous work, we described the use of starch-based microparticles as vehicles for the controlled release of corticosteroids. The goal of the present work is to evaluate the potential of these microparticles to incorporate and release platelet-derived growth factor (PDGF). The loading efficiency and release profile were evaluated, and PDGF was incorporated into and released from the matrix of starch-based ...


The effect of starch and starch-bioactive glass composite microparticles on the...

Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.

There is a clear need for the development of microparticles that can be used simultaneously as carriers of stem/progenitor cells and as release systems for bioactive agents, such as growth factors or differentiation agents. In addition, when thinking on bone-tissueengineering applications, it would be very useful if these microparticles are biodegradable and could be made to be bioactive. Microparticles with al...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia