Encontrados 3 documentos, a visualizar página 1 de 1
Fluorescence properties of a potential antitumoral benzothieno[3,2-b]pyrrole in...
Castanheira, Elisabete M. S.; Abreu, Ana S.; Queiroz, Maria João R. P.; Ferreira, Paula M. T.; Coutinho, Paulo J. G.; Nazareth, N.Fluorescence properties of the antitumoral methyl 3-(benzo[b]thien-2-yl)-benzothieno[3,2-b]pyrrole-2-carboxylate (BTP) were studied in solution and in lipid bilayers of dipalmitoyl phosphatidylcholine (DPPC), dioleoyl phosphatidylethanolamine (DOPE) and egg yolk phosphatidylcholine (Egg-PC). BTP presents good fluorescence quantum yields in all solvents studied (0.20 ≤ ΦF ≤ 0.32) and a bathochromic shift in pola...
Synthesis and antitumour evaluation of benzopsoralen analogues
Oliveira, Ana M. A. G.; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Raposo, M. Manuela M.; Machado, António E. H.; Nascimento, Maria São JoséThe synthesis of five new analogues of benzopsoralens, derived from xanthen-9-one and carbazole is described. The preparation of the hydroxylated precursors, their formylation and the formation of the pyranone ring, by the reaction between ortho-formylated heterocycles and diethyl malonate in EtOH, will be discussed. The inhibitory effect on the growth of human tumour cell lines (MCF-7, SF-268 and NCI-460) of t...
Myxoma of the mitral valve
Rocha,Antônio Sérgio C.; Ferreira,Maria Elizabeth; Dutra,Paulo R.; Rocha,Nazareth N.; Tinoco,Solange M.; Nascimento,Cesar; Grandelle,RosanaOnly rarely do myxomas originate from the mitral valve. This is the report of a 49-year-old woman presenting with congestive heart failure. The diagnosis of an intracardiac tumor involving the anterior cuspid of the mitral valve was made by transesophageal echocardiography. The patient underwent surgery for tumor resection and plasty of the valve was made with reconstruction and preservation of the valve. The d...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||