To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...
The capital city of Lisbon and the Lower Tagus Valley region of central Portugal mainland are located in the Eurasian plate about 350 Km from the approximately E-W oriented Eurasia-Africa plate boundary. It is characterized by low slip-rates (<0.4 mm/year) and a moderate seismicity, occasionally shaken by some important historical earthquakes causing significant damages and economical losses. The most well know...
The capital city of Lisbon and the Lower Tagus Valley region of central Portugal mainland are located in the Eurasian plate about 350 Km from the approximately E-W oriented Eurasia-Africa plate boundary. It is characterized by low slip-rates (<0.4 mm/year) and a moderate seismicity, occasionally shaken by some important historical earthquakes causing significant damages and economical losses. The most well know...
The evaluation of site effects on a broad scale is a critical issue for seismic hazard and risk assessment, land use planning and emergency planning. As characterization of site conditions based on the shear-wave velocity has become increasingly important, several methods have been proposed in the literature to estimate its average over the first thirty meters (Vs30) from more extensively available data. These ...
O Instituto Geofísico da Universidade de Coimbra (IGUC) foi fundado em 1864 como observatório meteorológico. As observações sísmicas só terão sido iniciadas de forma regular 43 anos mais tarde, em 1907. Os registos sísmicos que o IGUC possui actualmente representam uma das maiores e melhor conservadas séries de registos sísmicos a nível mundial. Neste trabalho apresentaremos os registos e os instrumentos utiliz...
Tetanus continues to be a frequent illness with a high rate of mortality which mainly affects the elderly. In view of this, 54 cases treated in the ICU between 1983 and 1991 were studied. The clinical support with mechanical ventilation and the use of new drugs, which allowed for a more satisfactory sedation and muscular relaxation, and which permitted the control of the autonomic overactivity, were the most de...
Financiadores do RCAAP | |||||||
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