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Molecular aspects and comparative genomics of bacteriophage endolysins

Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with a widespread group of bacterial hosts. At the end of the infection cycle, progeny virions are confronted with a rigid cell wall that hinders their release into...

Bacteriophage tree of life

RecFinder – a new tool to find phage proteins responsible for host recognition

(Bacterio)phages are bacterial viruses that represent the most abundant and genetically diverse biological entities on the planet [1,2]. The largest virus group, the order Caudovirales (containing 96% of all known phages), has evolved recognition peptides for efficient virus-host interaction [3]. The peptides, usually located at the phage tail fiber, baseplate and other tail proteins mediate recognition and att...

Host-Endolysins interactions

37 Host-Endolysins interactions Franklin L. Nobrega, Silvio Santos, Eugénio C. Ferreira, Joana Azeredo, Leon D. Kluskens IBB – Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal Abstract (Bacterio)phages are viruses that specifically infect bacteria. They are tremendously diverse and the most abundant living entiti...

Molecular and functional aspects of bacteriophage endolysins

Insights into phage endolysins

(Bacterio)phages are viruses that specifically infect bacteria, and thus are harmless to humans, animals, and plants. They are the most abundant microorganisms on the planet (estimated to be 1031 on Earth) in a ratio of 10 times more than bacteria (1). Consequently, even rare phage-induced events are frequent at the global level. Therefore, they have a staggering ecological impact on the bacterial population an...

Unraveling the insights into phage endolysin association

In view of the abundacy of phages (1), even rare phage-induced events are frequent at the global level. They have a staggering ecological impact on the bacterial population and in the evolution of bacterial genomic structure upon virus-host interactions, acting as agents in the recycling of organic matter and presenting a valuable tool in molecular biology and epidemiology. Th focus on genomic research have rev...

The role of flagellum and flagellum-based motility on Salmonella Enteritidis an...

Anticonvulsant activity of thymoquinone and its structural analogues

It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity o...

Heavy-metal resistance in Marinobacter aquaeolei 617 insights into copper resis...

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Biotecnologia ; Heavy metal resistance in Marinobacter aquaeolei (Ma.aq) 617 in aerobic conditions was studied for three different ions, cadmium, cobalt and copper. The main aim of this work was the study of a putative copper resistance operon, copSRXAB, located in the chromosome of M...