Encontrados 8 documentos, a visualizar página 1 de 1
A bacteriophage detection tool for viability assessment of Salmonella cells
Fernandes, E.; Martins, V. C.; Nóbrega, Cláudia; Carvalho, Carla A. O. C. M.; Cardoso, F. A.; Cardoso, S.; Dias, J.; Deng, D.; Kluskens, LeonAvailable online 7 September 2013 ; Salmonellosis, one of the most common food and water-borne diseases, has a major global health and economic impact. Salmonella cells present high infection rates, persistence over inauspicious conditions and the potential to preserve virulence in dormant states when cells are viable but non-culturable (VBNC). These facts are challenging for current detection methods. Culture...
Poor immune reconstitution in HIV-infected patients associates with high percen...
Horta, Ana; Nóbrega, Cláudia; Machado, Pedro Amorim; Teixeira, Vítor Emanuel Coutinho; Silva, Palmira Barreira; Boavida, Susana; Costa, Patrício SoaresCD4(+) regulatory T cells (Tregs) are essential for the maintenance of the immune system's equilibrium, by dampening the activation of potential auto-reactive T cells and avoiding excessive immune activation. To correctly perform their function, Tregs must be maintained at the right proportion with respect to effector T cells. Since this equilibrium is frequently disrupted in individuals infected with the human...
T Cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio; Rodrigues, Bruno Cerqueira; Roque, Susana; Silva, Palmira Barreira; Behar, Samuel M.; Neves, Margarida CorreiaThe thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
T cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio Nunes; Rodrigues, Bruno Miguel Cerqueira; Roque, Susana; Silva, Palmira Barreira da; Behar, Samuel M.The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
Tolerance has its limits : how the thymus copes with infection
Alves, Cláudio; Nóbrega, Cláudia; Correia-Neves, MargaridaThe thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that a...
Differential expression of food enterococci in response to distinct growth envi...
Nóbrega, Cláudia Raquel da Silva, 1988-Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2011 ; Enterococci contribute to the organoleptic characteristics of several fermented foods, but during the last decades they have emerged as increasingly important causes of healthcare-associated infections. In the present investigation, in order to assess for the role of environmental cues in the modulation o...
Interplay between depressive-like behavior and the immune system in an animal m...
Roque, Susana; Oliveira, Tiago Gil; Nóbrega, Cláudia; Silva, Palmira Barreira; Alves, Cláudio Nunes; Sousa, Nuno; Palha, Joana AlmeidaGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression,...
Infection of the thymus by micobacteria: potential impact on the immune respons...
Nóbrega, Cláudia Rubina Freitas Pereira deDoutoramento em Ciências Biomédicas
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||