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Nanoencapsulation of bovine lactoferrin for food and biopharmaceutical applicat...

Balcão, V. M.; Costa, Carla Isabel; Matos, Carla M.; Moutinho, C.; Amorim, Manuela; Pintado, Manuela E.; Gomes, Ana P.; Vila, Marta M.; Teixeira, J. A.

Lactoferrin has for long captured the interest of many researchers as a natural compound with a wide variety of uses. Lactoferrin is a monomeric, iron-binding 80 kDa glycoprotein, and appears to be the subfraction of whey with the best documented antiviral, antimicrobial, anticancer and immune modulating/enhancing effects. It belongs to the family of transferrin proteins, and serves to control iron levels in bo...


Liposomes as a model for the biological membrane : studies on daunorubicin bila...

Matos, C.; Moutinho, C.; Lobão, P.

In this study the interaction of the antitumoral drug daunorubicin with egg phosphatidylcholine (EPC) liposomes, used as a cell membrane model, was quantified by determination of the partition coefficient (Kp). The liposome/aqueous-phase Kp of daunorubicin was determined by derivative spectrophotometry and measurement of the zeta-potential. Mathematical models were used to fit the experimental data, enabling de...


Structural and functional stabilization of glycomacropeptide via encapsulation ...

Moutinho, C.; Teixeira, J. A.; Balcão, V. M.

Bovine glycomacropeptide (GMP), derived from whey proteins, has been demonstrated to possess an interesting bioactivity that has attracted a lot of attention over the last few years. In particular, its ability to bind Vibrio cholerae and Escherichia coli enterotoxins, inhibit bacterial and viral adhesion, suppress gastric secretions, promote bifidobacterial growth and modulate immune system responses. Of these,...


Biopolymeric matrices for structural and functional stabilization of bacterioph...

Balcão, V. M.; Moreira, Ana R.; Moutinho, C.; Teixeira, J. A.

In the recent past years, bacteriophage research has experienced a renaissance due to their potential application in the pharmaceutical field, especially with the increase of bacterial resistance to antibiotics and the possibility to take part in new methods of early detection and diagnosis of bacterial infections. In that context, the structural and functional stabilization of bacteriophages using biopolymeric...




Total antioxidant activity and trace elements in human milk : the first 4 month...

Matos, C.; Moutinho, C.; Balcão, V. M.; Almeida, Cristina; Ribeiro, Marta; Marques, A. F.; Guerra, A.

The content of many nutrients in breast milk are dependent on the nutritional status of the lactating woman. This is particularly true for fat and water-soluble vitamins, some of which have antioxidant properties. The aim of the study entertained herein was to evaluate the changes in total antioxidant status of human milk during the first 4 months of lactation, and to correlate such changes with the contents in...


A multiple emulsion formulation of bacteriophage encapsulated in lipid nanovesi...

Balcão, V. M.; Azevedo, André Filipe; Castro, Luís Miguel; Costa, Carla Isabel; Santos, Sílvio; Matos, Carla Manuela; Moutinho, C.; Teixeira, J. A.



Gestão do ambiente e da segurança em laboratórios de ensino

Fonseca, Ana; Oliveira, Gisela; Castro, Maria João; Moutinho, C.

As universidades têm a capacidade e a responsabilidade de promoverem o desenvolvimento pelo ambiente e pela segurança, transmitindo valores e saberes, e comportando-se de forma social e ambientalmente responsável. Neste trabalho faz-se uma análise da forma como é feita a gestão do ambiente e da segurança no Laboratório de Química da Faculdade de Ciência e Tecnologia da Universidade Fernando Pessoa, identificand...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia