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The role of B cells in the early phase of rheumatoid arthritis

Tese de doutoramento, Ciências Biomédicas (Imunologia), Universidade de Lisboa, Faculdade de Medicina, 2011 ; Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease of unknown aetiology that affects around 1% of the world population. RA is characterized by symmetric polyarthritis associated with pain and swelling in multiple joints. If left untreated, RA leads to joint destruction, functional disa...