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The Aging Profile of the Portuguese Population: A Principal Component Analysis
Rodrigues, Vítor; Mota-Pinto, Anabela; de Sousa, Bruno; Botelho, Amália; Alves, Catarina; Resende de Oliveira, CatarinaIn the last 5 years the resident population of Portugal has increased 2.3 %, along with a progressive ageing. This study aims assessing the social dependence and frailty, as well as social and familial support needs of the elderly. In an observational, cross-sectional community based study (EPEPP study), a total of 2,672 people, aged 55 or more, were submitted to an enquiry and several variables were studied am...
Polycyclic Aromatic Hydrocarbons May Contibute for Prostate Cancer Progression
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana; Mota-Pinto, AnabelaProstate cancer is the most common form of cancer affecting men in the Western world. Risk factors include ageing, genetics, recurrent inflammation, lifestyle and diet intake, related to an increase of oxidative stress. Prostate cancer risk is also associated with exposure to carcinogen such as polycyclic aromatic hydrocarbons (PAHs), originated from the incomplete combustion of carbon-containing fuels like tob...
CD4+, CD8+ AND CD19+ Cells at Individuals with Dyslipidemia
Pereira de Moura, Jose; Serviço de Medicina Interna. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Introduction: The past decade has witnessed an increasing recognition that inflammatory mechanisms play a central role in the pathogenesis of atherosclerosis and its complications. Recently, attention was focused on the potential role of plasma markers of inflammation as risk predictors among those at risk for cardiovascular events. Of these potential markers, C-reactive protein (CRP), IL6, metalloproteinases, ...
Populações Celulares Periféricas (CD4+, CD8+ e CD19+) em Indivíduos Dislipidémi...
Pereira de Moura, José; Santos Rosa, Manuel; Alves, Vera; Mota-Pinto, Anabela; Rodrigues, Vítor; Silva, José Manuel; Alves de Moura, JJIntrodução: Os mecanismos imunológicos e inflamatórios têm um papel crucial no desenvolvimento da aterosclerose e na sua tradução clínica. São inúmeros os estudos que procuraram relacionar os mais diversos marcadores inflamatórios – leucócitos, proteína C reactiva, interleucinas, quimiocinas, moléculas de adesão, metaloproteinases, etc – com os factores de risco clássicos da aterosclerose, a formação da placa e...
Human periprostatic adipose tissue promotes prostate cancer aggressiveness in v...
Ribeiro, Ricardo; Monteiro, Cátia; Cunha, Virgínia; Oliveira, Maria José; Freitas, Mariana; Fraga, Avelino; Príncipe, Paulo; Lobato, CarlosBackground - Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer. Methods - Supernatants of whole adipose tissue (explants) or ...
Oxidative stress adaptation in aggressive prostate cancer may be counteracted b...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
Aging and asthma - Changes in CD45RA, CD29 and CD95 T cells subsets
Todo-Bom, Ana; Mota-Pinto, Anabela; Alves, Vera; Santos-Rosa, ManuelBackground: Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells. Apoptosis is a key mechanism to clear the immune system from activated and harmful cells. In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells. The aim of this work was to evaluate the imbalance between CD45...
Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate can...
Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, AnabelaDocetaxel and sodium selenite are well known for their anticancer properties. While resistance to docetaxel remains an obstacle in prostate cancer chemotherapy, sodium selenite, has been exploited as a new therapeutic approach. Currently, development of therapies affecting a multitude of cell targets, have been proposed as a strategy to overcome drug resistance. This association may reduce systemic toxicity cou...
Regulatory T Cells in Elderly Patients With Asthma
Mota-Pinto, Anabela; Todo-Bom, Ana; Alves, Vera; Santos, Alexandra; Santos-Rosa, ManuelBackground: Airway walls in asthma present an accumulation of activated cells that determine bronchial structural changes and disease progression and severity. During the aging process, the immunoinflammatory response changes as a consequence of chronic antigenic stress. Objective: To evaluate T-cell subsets with regulatory functions associated with asthma in elderly patients. Methods: A group of 153 individual...
FoxP3, GATA-3 and T-bet expression in elderly asthma
Vale-Pereira, Sofia; Todo-Bom, Ana; Geraldes, Luisa; Schmidt-Weber, Carsten; Akdis, Cesmi; Mota-Pinto, AnabelaBackground Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation hile T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to ...
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