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Common genetic polymorphisms in the ABCB1 gene are associated with risk of majo...
Santos, Marlene; Carvalho, Serafim; Lima, Luís; Nogueira, Augusto; Assis, Joana; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, DianaMajor depressive disorder (MDD) is a highly prevalent disorder, which has been associated with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis. Reports have argued that an abnormal HPA axis response can be due to an altered P-Glycoprotein (P-GP) function. This argument suggests that genetic polymorphisms in ABCB1 may have an effect on the HPA axis activity; however, it is still not clear i...
Moderate exercise as an adjuvant therapy for treatment-resistant major depressi...
Mota-Pereira, Jorge; Silvério, Jorge Manuel Amaral; Fonte, Daniela; Carvalho, Serafim; Ramos, Joaquim; Ribeiro, José CarlosAlthough several international guidelines recommend exercise to reduce symptoms of Major Depressive Disorder (MDD), data concerning the long-term effects of exercise in depression are still extremely scarce. Therefore, and in order to assess these long-term effects, we have evaluated treatment-resistant MDD patients previously enrolled in a moderate intensity 12 week exercise program at 3 and 6 months after...
Exercise intervention in treatment-resistant major depressive disorder : benefi...
Mota-Pereira, Jorge; Ribeiro, José Carlos; Fonte, Daniela; Carvalho, Serafim; Ramos, Joaquim; Silvério, Jorge Manuel AmaralAlthough there are several reports on the benefits of exercise on Major Depressive Disorder, none has monitored these exercise programs with accelerometers. We have conducted a 12 week home based moderate intensity exercise program in 33 treatmentresistant Major Depressive Disorder patients and, based on accelerometer data, determined compliance, exercise patterns and relationship between time spent in MVPA...
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