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Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
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