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Early skin immunological disturbance after Plasmodium-infected mosquito bites
Silva, Henrique Borges da; Caetano, Susana S; Monteiro, Isadora; Gómez-Conde, Iván; Hanson, Kirsten; Penha-Gonçalves, Carlos; Olivieri, David NAlthough the role of regulatory T cells (Tregs) during malaria infection has been studied extensively, such studies have focused exclusively on the role of Treg during the blood stage of infection; little is known about the detailed mechanisms of Tregs and sporozoite deposition in the dermis by mosquito bites. In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobilit...
Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated ...
Gomes-Santos, Carina S. S.; Braks, Joanna; Prudêncio, Miguel; Carret, Céline; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; Khan, ShahidMany eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced dur...
VEGF promotes malaria-associated acute lung injury in mice
Epiphanio, Sabrina; Campos, Marta G.; Pamplona, Ana; Carapau, Daniel; Pena, Ana C.; Ataíde, Ricardo; Monteiro, Carla A. A.; Félix, Nuno© 2010 Epiphanio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of di...
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