Encontrados 2 documentos, a visualizar página 1 de 1
Intramolecular C–H insertion catalyzed by dirhodium(II) complexes using CO2 as ...
Zakrzewska, Malgorzata E.; Cal, Pedro M.S.D.; Candeias, Nuno R.; Bogel-Lukasik, R.; Afonso, Carlos A.M.; Ponte, Manuel Nunes; Gois, Pedro M.P.In this work, the intramolecular C–H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C–H insertion was also achieved and the β-lactam 14 was obtained in >97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh2(S-PTTL)4. Finally, the dirhodium(II) complex Rh2(OAc)...
Inserção C-H de carbenóides de ródio em água e reutilização do catalisador
Candeias,Nuno R.; Gois,Pedro M. P.; Afonso,Carlos A. M.A five-session laboratory experiment is described for the synthesis of a beta-lactam via Rh(II) catalysed intramolecular C-H insertion of a alpha-diazo-alpha-ethoxycarbonylacetamide. The metallo-carbene, responsible for the C-H bond activation, was generated from the diazo substrate and the catalyst Rh2(OAc)4. The high stability and solubility of the catalyst and the exclusive C-H insertion of the Rh-carbene al...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||