Encontrados 5 documentos, a visualizar página 1 de 1
Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...
Carrascal, M; Severino, P; Cabral, MG; Silva, M; Ferreira, JA; Calais da Silva, F; Quinto, H; Pen, C; Ligeiro, D; Lara Santos, L; Dall'Olio, FDespite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portugues...
Pimentel-Santos, FM; Ligeiro, D; Matos, M; Mourão, AF; Sousa, E; Pinto, P; Ribeiro, A; Sousa, M; Barcelos, A; Godinho, F; Cruz, M; Fonseca, JEOBJECTIVE: Association between ankylosing spondylitis (AS) and two genes, ERAP1 and IL23R, has recently been reported in North American and British populations. The population attributable risk fraction for ERAP1 in this study was 25%, and for IL23R, 9%. Confirmation of these findings to ERAP1 in other ethnic groups has not yet been demonstrated. We sought to test the association between single nucleotide polym...
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portugues...
Pimentel-Santos, FM; Ligeiro, D; Matos, M; Mourão, AF; Sousa, E; Pinto, P; Ribeiro, A; Sousa, M; Barcelos, A; Godinho, F; Cruz, M; Fonseca, JEOBJECTIVE: Association between ankylosing spondylitis (AS) and two genes, ERAP1 and IL23R, has recently been reported in North American and British populations. The population attributable risk fraction for ERAP1 in this study was 25%, and for IL23R, 9%. Confirmation of these findings to ERAP1 in other ethnic groups has not yet been demonstrated. We sought to test the association between single nucleotide polym...
Espondilite Anquilosante e sua Base Genética
Pimentel dos Santos, F. M.; Bastos, Estela; Ligeiro, D.; Mourão, A. F.; Chaves, Raquel; Trindade, H.; Guedes-Pinto, Henrique; Branco, J. C.
Impact of Donor and Recipient Cytokine Genotypes on Renal Allograft Outcome
Ligeiro, D; Sancho, MR; Papoila, A; Barradinhas, AM; Almeida, A; Calão, S; Machado, D; Nolasco, F; Guerra, J; Sampaio, MJ; Trindade, HAllelic differences in gene promoter or codifying regions have been described to affect regulation of gene expression, consequently increasing or decreasing cytokine production and signal transduction responses to a given stimulus. This observation has been reported for interleukin (IL)-10 (-1082 A/G; -819/-592 CT/CA), transforming growth factor (TGF)-beta (codon 10 C/T, codon 25 G/C), tumor necrosis factor (TN...
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