Encontrados 53 documentos, a visualizar página 1 de 6
Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphin...
Cunha-Oliveira, Teresa; Silva, Lisbeth; Silva, Ana Maria; Moreno, António J.; Oliveira, Catarina R.; Santos, Maria S.Mitochondrial function and energy metabolism are affected in brains of human cocaine abusers. Cocaine is known to induce mitochondrial dysfunction in cardiac and hepatic tissues, but its effects on brain bioenergetics are less documented. Furthermore, the combination of cocaine and opioids (speedball) was also shown to induce mitochondrial dysfunction. In this work, we compared the effects of cocaine and/or mor...
Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to...
Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J.Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitoch...
In vitro surfactant structure-toxicity relationships: implications for surfacta...
Inácio, Ângela S; Mesquita, Katia A; Jordão, Luísa; Santos, Maria S; Moreno, António J M; Vaz, Winchil L C; Vieira, Otília VSexually transmitted infections (STIs) are a major public-health problem worldwide. According to the World Health Organization there are 340 million new cases of bacterial and protozoal STIs (Gonorrhea, Syphilis, Chlamydia and Trichomoniasis) per year. The direct treatment costs and serious perinatal collateral damage caused by STIs represent hefty financial and social burdens, particularly in developing countr...
Antioxidant activity of synthetic diarylamines: A mitochondrial and cellular ap...
Pinto-Basto, Diana; Silva, João P.; Queiroz, Maria-João R. P.; Moreno, António J.; Coutinho, Olga P.http://www.sciencedirect.com/science/article/B6W8G-4TNWGYP-1/2/ba77631bc763067dea4a5c7406e740c9
An easy and direct method for the synthesis of 1,2,4-triazole derivatives throu...
Rivera,Gildardo; Bocanegra-Garcia,Virgilio; Moreno,Antonio; Galiano,Silvia; Pérez,Silvia; Aldana,Ignacio; Monge,AntonioWe have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synth...
Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-121...
Fernandes, Maria A. S.; Pereira, Susana P. S.; Jurado, Amália S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Duburs, GunarsThe 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in positions 3 and...
Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--Nuclear vs. mitocho...
Serafim, Teresa L.; Matos, Júlio A.C.; Sardão, Vilma A.; Pereira, Gonçalo C.; Branco, Ana F.; Pereira, Sandro L.; Parke, Donna; Perkins, Edward L.http://www.sciencedirect.com/science/article/B6T4P-4T193YB-5/2/8b89adb1a424a742b294db27ed9982c6
Mitochondria as the target for mildronate's protective effects in azidothymidin...
Pupure, Jolanta; Fernandes, Maria A. S.; Santos, Maria S.; Moreno, António J. M.; Kalvinsh, Ivars; Klusa, Vija; Oliveira, Catarina R.Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardiotoxicity model in vivo (in mice), we have found mildronate's ability of protecting heart tissu...
Sildenafil citrate concentrations not affecting oxidative phosphorylation depre...
Fernandes, Maria; Marques, Ricardo; Vicente, Joaquim; Santos, Maria; Monteiro, Pedro; Moreno, António; Custódio, JoséAbstract Sildenafil citrate (Viagra) is a potent and specific inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which exhibits cardioprotective action against ischemia/reperfusion injury in intact and isolated heart. The mechanism of its cardioprotective action is not completely understood, but some results suggested that sildenafil exerts cardioprotection through the...
Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-...
Moreira, Paula I.; Custódio, José B.A.; Nunes, Elsa; Moreno, António; Seiça, Raquel; Oliveira, Catarina R.; Santos, Maria S.Given the tremendous importance of mitochondria to basic cellular functions as well as the critical role of mitochondrial impairment in a vast number of disorders, a compelling question is whether 17[beta]-estradiol (E2) modulates mitochondrial function. To answer this question we exposed isolated liver mitochondria to E2. Three groups of rat females were used: control, ovariectomized and ovariectomized treated...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||