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Moderate exercise training provides left ventricular tolerance to acute pressur...
Moreira-Gonçalves, D; Henriques-Coelho, T; Fonseca, H; Ferreira, RM; Amado, F; Leite Moreira, A; Duarte, JAThe present study evaluated the impact of moderate exercise training on the cardiac tolerance to acute pressure overload. Male Wistar rats were randomly submitted to exercise training or sedentary lifestyle for 14 wk. At the end of this period, the animals were anaesthetized, mechanically ventilated, and submitted to hemodynamic evaluation with biventricular tip pressure manometers. Acute pressure overload was ...
Apelin decreases myocardial injury and improves right ventricular function in m...
Falcão-Pires, I; Gonçalves, N; Henriques-Coelho, T; Moreira-Gonçalves, D; Roncon-Albuquerque R, Jr.; Leite-Moreira, AFWe investigated the endogenous production of apelin and the cardiac and pulmonary effects of its chronic administration in monocrotaline (MCT)-induced pulmonary hypertension (PH). Male Wistar rats were injected with MCT (60 mg/kg sc) or vehicle (day 0). One week later, these animals were randomly treated during 17 days with pyroglutamylated apelin-13 (Pyr-AP13; 200 microg*kg(-1)*day(-1) ip) or a similar volume ...
Effect of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension
Henriques-Coelho, T; Brandão-Nogueira, A; Moreira-Gonçalves, D; Correia-Pinto, J; Leite-Moreira, AFINTRODUCTION: TNF-alpha blockade in ischemic heart failure is still the subject of debate since clinical trials show conflicting results. However, its benefit in heart failure secondary to pulmonary hypertension has yet to be determined. It has been reported that transgenic rats overexpressing TNF-alpha develop pulmonary hypertension. The aim of this study was to assess the morphologic and hemodynamic effects o...
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