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3-Oxoandrosta-4,6-dien-17[beta]-yl 2-methyl-1H-imidazole-1-carboxylate and 3-ox...
Silva, Manuela Ramos; Moreira, Vânia M.; Cardoso, Cláudia; Beja, Ana Matos; Salvador, Jorge A. R.The title compounds, C24H30N2O3, (I), and C24H34N2O3, (II), both contain an androstane backbone and a 2-methylimidazole-1-carboxylate moiety at the 17-position. Compound (I) contains two symmetry-independent molecules (denoted 1 and 2), while compound (II) contains just one molecule in the asymmetric unit. The C-C-O-C torsion angle that reflects the twisting of the 2-methylimidazole-1-carboxylate moiety from th...
Conformation of 17-chloro-16-formylandrosta-5,16-dien-3[beta]-yl acetate and 17...
Silva, Manuela Ramos; Moreira, Vânia M.; Cardoso, Cláudia; Beja, Ana Matos; Salvador, Jorge A. R.In the title compounds, C22H29ClO3, (I), and C21H29ClO2, (II), respectively, the B rings adopt a half-chair conformation and the D rings adopt an envelope conformation. A twist of the steroid skeleton of both compounds is observed. There is a positional disorder of the acetoxy group of (II), with the terminal atoms disordered over two positions with near equal occupancy. Quantum-mechanical ab initio calculation...
Synthesis and evaluation of novel 17-indazole androstene derivatives designed a...
Moreira, Vânia M. A.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Salvador, Jorge A. R.A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
Synthesis and evaluation of novel 17-indazole androstene derivatives designed a...
Moreira, Vânia M. A.; Vasaitis, Tadas S.; Njar, Vincent C. O.; Salvador, Jorge A. R.A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17[alpha]-hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines. ; http://www.sciencedirect.com/science/article/B6TC9-4PF1WHS-2/1/094a9de6c64...
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