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Cancer cell bioenergetics and pH regulation influence breast cancer cell resist...
Valente, Diana Tavares; Baltazar, Fátima; Moreira, Roxana; Queirós, OdíliaThe multidrug resistance (MDR) phenotype, frequently observed during cancer treatment, is often associated with drug efflux pump activity. However, many other factors are also known to be involved. Cancer cells often rely on aerobic glycolysis for energy production; this is known as the "Warburg effect" and is used as a survival mechanism. Associated to this event, a reverse pH gradient across the cell membrane...
3-bromopyruvate, butyrate, monocarboxylate transporters, warburg effect
Queirós, Odília; Preto, Ana; Pacheco, António; Pinheiro, Céline; Silva, João Azevedo; Moreira, Roxana; Pedro, Madalena; Ko, Young; Pedersen, PeterThe authors are deeply grateful to Professor André Goffeau (Université Catholique de Louvain-la-Neuve, Belgium) for his contagious vision, valuable discussions at the Conference on 3-BP held in Brussels, 29 October–2 November, 2011 and critical reviewing of the manuscript. The authors also thank Dr. Rita Reis for her technical support in microscopy and image analysis. ; Most malignant tumors exhibit theWarburg...
Functional characterization of a yarrowia lipolytica gene family coding for car...
Bessa, Daniela; Paiva, Sandra; Moreira, Roxana; Casal, Margarida; Queirós, OdíliaCarboxylic acids are widely used in pharmaceutical and food industries and new industrial uses are continually emerging. The first step of carboxylic acids metabolism is their entrance to the cell and understanding in detail this process has significant biotechnological relevance. The first carboxylic acids permease found in Saccharomyces cerevisiae was a lactate/H+ symporter coded by JEN1 gene. In Kluyveromyce...
Evidências da multifuncionalidade da proteína p37 de kluyveromyces marxianus
Moreira, Roxana Esmeriz FalcãoDissertação de Doutoramento em Ciências Biomédicas apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto
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