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RKIP Inhibition in cervical cancer Is associated with higher tumor aggressive b...
Martinho, Olga; Pinto, Filipe; Granja, Sara Costa; Gonçalves, Vera M.; Longatto Filho, Adhemar; Reis, R. M.; Loreto, Celso di; Rosner, Marsha R.Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however its role on cervical cancer is unclear. In the present study, 259 uterine cervix tissues, including cervicitis, cervical intraepithelial ...
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous...
Longatto Filho, Adhemar; Pinheiro, C??line; Martinho, Olga Catarina Lopes; Moreira, Marise A. R.; Ribeiro, Luiz F. J.; Queiroz, Geraldo S.Art. No. 212 ; BACKGROUND: Adenosquamous carcinoma of the uterine cervix is an infrequent but aggressive subtype of cervical cancer. A better understanding of its biological behaviour is warranted to define more accurate prognosis and therapeutic targets. Currently, the blockage of receptor tyrosine kinase (RTKs) activity is an efficient therapeutic strategy for many different cancers. The objective of this st...
Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carc...
Pinheiro, Celine; Baltazar, F??tima; Longatto Filho, Adhemar; Pereira, S??nia Maria Miranda; Etlinger, Daniela; Moreira, Marise A. R.; Jub??, L. F.Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH maintenance. Still, the molecular mechanisms underlying the reg...
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