Encontrados 14 documentos, a visualizar página 1 de 2
Cardiotoxicity associated with cancer therapy: pathophysiology and prevention s...
Adão, Rui; Keulenaer, G.; Moreira, Adelino; Silva, CarmenCardiotoxicity is one of the most significant adverse effects of cancer treatment, and is responsible for considerable morbidity and mortality. Among the effects of chemotherapeutic agents on the cardiovascular system, the most frequent and serious is heart failure with ventricular systolic dysfunction. Other toxic effects include hypertension, thromboembolic disease, pericardial disease, arrhythmias and myocar...
Rodent models of heart failure: an updated review
Gomes, A.; Pires, I.; Pires, A.; Silva, Carmen Brás; Moreira, AdelinoHeart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial structure and function and to follow its progression toward HF. Indeed, during the past 40 years, basic and translational scientists have used small animal models to ...
Intraventricular pressure gradients in heart failure
Guerra, Miguel; Silva, Carmen Brás; Amorim, Mário; Bento, Cláudia; Bastos, Pedro; Moreira, AdelinoThe aim of the present study was to characterize intraventricular pressure gradients (IVPGs) in an animal model of chronic heart failure. New Zealand rabbits were treated with doxorubicin (heart failure group, n=5) or saline (control group, n=5) and instrumented with pressure catheters placed in the apex and outflow-tract of left ventricle (LV) and with sonomicrometer crystals placed in the apex and base of the...
Papel da titina na modulação da função cardíaca e suas implicações fisiopatológ...
Castro-Ferreira,Ricardo; Fontes-Carvalho,Ricardo; Falcão-Pires,Inês; Leite-Moreira,Adelino F.A titina é uma proteína sarcomérica gigante que se estende desde a linha Z até a linha M. Em razão de sua localização, representa um importante sensor biomecânico com um papel fundamental na manutenção da integridade estrutural do sarcômero. A titina funciona como uma "mola bidirecional" que regula o comprimento sarcomérico e realiza ajustes adequados da tensão passiva sempre que o comprimento varia. Dessa form...
Neuregulin attenuates right ventricular hypertrophy and dysfunction in an exper...
Ferreira, P. Mendes; Rocha, C. Maia; Adão, R.; Silva, M.; Mendes, M.; Lourenço, A.; Cerqueira, R.; Chaves, P. Castro; De Keulenaer, G.[abstract] ; [resumo]
Modulation of myocardial stiffness by beta-adrenergic stimulation - its role in...
Falcão-Pires, I.; Sousa, Adelino Fontes; Conceiçao, L. Lopes; Brás-Silva, Carmen; Leite-Moreira, AdelinoThe acute effects of beta-adrenergic stimulation on myocardial stiffness were evaluated. New-Zealand white rabbits were treated with saline (control group) or doxorubicin to induce heart failure (HF) (DOXO-HF group). Effects of isoprenaline (10(-10)-10(-5) M), a non-selective beta-adrenergic agonist, were tested in papillary muscles from both groups. In the control group, the effects of isoprenaline were also e...
Neuregulin attenuates right ventricular hypertrophy and dysfunction in an exper...
Ferreira, P. Mendes; Rocha, C. Maia; Adão, R.; Silva, M.; Lourenço, A.; Leite-Moreira, Adelino; Brás-Silva, Carmen[abstract] ; [resumo]
Left intraventricular diastolic and systolic pressure gradients
Guerra, Miguel; Sampaio, Francisco; Brás-Silva, Carmen; Leite-Moreira, AdelinoTo describe left ventricular (LV) function comprehensively, it is crucial to characterize precisely transmitral, intraventricular and transaortic pressure-flow relations. The site of measurement is important; as the measurement location is moved from the mitral valve toward the apex and the outflow tract, important regional pressure differences are recorded inside the LV. These intraventricular pressure gradien...
Alpha-Adrenergic Stimulation Increases Myocardial Distensibility Through PKC Ac...
Sousa, Ana Fontes de; Silva, Carmen Brás; Cardoso, Vera Monteiro; Gonçalves, Nádia Pereira; Conceição, Luísa Lopes; Moreira, Adelino Leite[resumo]
O aumento da distensibilidade miocárdica induzido pela Urocortina 2 é dependent...
Silva, Carmen Brás; Almeida, Mónica; Mendes, Susana; Sousa, Ana Fontes de; Moreira, Adelino Leite[abstract] ; [resumo]
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