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Glucose evoked regulation of Na,K-ATPase activity in pancreatic beta-cells
Costa, A.C.R.; Real, Joana; Antunes, Célia M.; Morais, Júlio C.Glucose is the most important physiological insulin secretagogue. However, the mechanism of glucose-induced insulin release is not fully understood. The current dogma states that, in pancreatic -cell, glucose metabolism leads to an increase of ATP/ADP ratio, closure of ATP-sensitive K+ channels, membrane depolarization, opening of the voltage-dependent Ca2+ channels and Ca2+ influx which triggers insulin exocy...
Data: 2008
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Origem: Repositório Científico da Universidade de Évora
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