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Risk factors for bronchopulmonary dysplasia in five portuguese neonatal intensi...
Guimarães, H; Rocha, G; Vasconcellos, G; Proença, E; Carreira, ML; Sossai, MR; Morais, B; Martins, I; Rodrigues, T; Severo, MThe pathogenesis of bronchopulmonary dysplasia (BPD) is clearly multifactorial. Specific pathogenic risk factors are prematurity, respiratory distress, oxygen supplementation, mechanical ventilation (MV), inflammation, patent ductus arteriosus (PDA), etc. AIM: To evaluate BPD prevalence and to identify risk factors for BPD in five Portuguese Neonatal Intensive Care Units in order to develop better practices the...
Erythrocyte phosphoglucomutase activity of bipolar I patients currently using l...
Montero-Lomelí,M.; Galvão,D.; Morais,B.B.; Nardi,A.E.Lithium has been used for the last five decades to treat bipolar disorder, but the molecular basis of its therapeutic effect is unknown. Phosphoglucomutase is a key enzyme in the metabolism of glycogen. In yeast, rabbit and human HEK293 cells, it is inhibited by lithium in the therapeutic concentration range. We measured the phosphoglucomutase activity in erythrocytes and the inhibitor constant for lithium in a...
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