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Compensatory T-Cell Regulation in Unaffected Relatives of SLE Patients, and Opp...
Fesel, C.; Barreto, M.; Ferreira, R.C.; Costa, N.; Venda, L.L.; Pereira, C.; Carvalho, C.; Morães-Fontes, M.F.; Ferreira, C.M.; Vasconcelos, C.In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We studied relations of IgG autoantibody profiles and peripheral blood activated regulatory T-cells (aTregs), represented...
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated w...
Barreto, M.; Ferreira, R.C.; Lourenço, L.; Moraes-Fontes, M.F.; Santos, E.; Alves, M.; Carvalho, C.; Martins, B.; Andreia, R.; Viana, J.F.CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females...
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