Encontrados 35 documentos, a visualizar página 1 de 4

Monitoring Abacavir Bioactivation in Humans: Screening for an Aldehyde Metabolite

The anti-HIV drug abacavir is associated with idiosyncratic hypersensitivity reactions and cardiotoxicity. Although the mechanism underlying abacavir-toxicity is not fully understood, drug bioactivation to reactive metabolites may be involved. This work was aimed at identifying abacavir-protein adducts in the hemoglobin of HIV patients as biomarkers of abacavir bioactivation and protein modification. The protoc...

Predicted VO2 on 6 minutes walk test for FAP liver transplanted patients

Physical function is limited post-liver transplantation and exercise training can improve exercise capacity following transplantation but previously assessment of functional capacity is necessary. The 6 minute walk test (6MWT) is routinely used for studying patient’s exercise capacity and is less expensive and time consuming than a Cardiopulmonary Exercise Test (CPXT). There have been some studies looking at th...

Orthotopic Liver Transplantation in Familial Amyloidotic Polyneuropathy Is Asso...

Orthotopic liver transplantation has become the treatment of choice for familial amyloidotic polyneuropathy. The aims of this study were to evaluate the renal complications post orthotopic liver transplantation in familial amyloidotic polyneuropathy and their impact. We retrospectively studied 185 recipients who underwent 217 orthotopic liver transplants. Mean age 36.8±9.5 years, 59% males, 14.3% with renal dys...

Long-Term Maraviroc Use As Salvage Therapy in HIV-2 Infection

Evidence for Nevirapine Bioactivation in Man: Searching for the First Step in t...

Despite its efficacy, including in the prevention of vertical transmission, the antiretroviral nevirapine is associated with severe idiosyncratic hepatotoxicity and skin rash. The mechanisms underlying nevirapine toxicity are not fully understood, but drug bioactivation to reactive metabolites capable of forming stable protein adducts is thought to be involved. This hypothesis is based on the paradigm that drug...

Positron emission tomography in the detection of occult primary head and neck c...

BACKGROUND: The management of cervical lymph node metastases from an unknown primary tumor remains a controversial subject. Recently, Positron Emission Tomography (PET) has proved useful in the detection of these tumors, even after an unsuccessful conventional diagnostic workup. This study was performed to assess the role of PET in the detection of occult primary head and neck carcinomas. METHODS: A retrospecti...

Positron emission tomography in the detection of occult primary head and neck c...

BACKGROUND: The management of cervical lymph node metastases from an unknown primary tumor remains a controversial subject. Recently, Positron Emission Tomography (PET) has proved useful in the detection of these tumors, even after an unsuccessful conventional diagnostic workup. This study was performed to assess the role of PET in the detection of occult primary head and neck carcinomas. METHODS: A retrospecti...

Insuficiência cardíaca após enfarte agudo do miocárdio: revisão

Medicina ; Medicine

Transdutor de pressão, baseado nas características de fase do efeito GMI, desti...

Neste trabalho é apresentada a evolução de um transdutor de pressão para aplicações biomédicas, desenvolvido pelo Laboratório de Biometrologia da PUC-Rio. O mesmo utiliza-se do fenômeno da Magnetoimpedância Gigante (GMI) como elemento intermediário no processo de transdução, o qual compreende a conversão da grandeza pressão em campo magnético e, posteriormente, deste em tensão. Dentre as possíveis aplicações bi...

Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao ...

As pesquisas sobre ansiedade envolvem frequentemente o uso de modelos animais para investigação de compostos terapêuticos. Assim, o labirinto em cruz elevado (LCE) é um dos modelos mais utilizados em pesquisas que envolvem ansiedade e já foi validado para ratos e camundongos. A serotonina (5-HT) é um neurotransmissor envolvido não só na ansiedade, mas também em outros distúrbios. Alguns relatos na literatura mo...