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The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

Associação dos Fenótipos da Haptoglobina com os Lípidos e Apolipoproteínas Séri...

A aterosclerose e a hipertensão arterial iniciam-se precocemente na idade pediátrica, ainda que as expressões clínicas da doença cardio-cérebro-vascular se manifestem apenas na idade adulta. É objectivo primordial de numerosos estudos transversais e prospectivos a identificação dos principais factores risco, quer genéticos quer ambientais, relativamente ao processo aterosclerótico de modo a traçar estratégias d...

Treat to target: temporomandibular joint (TMJ) arthritis in children with juven...

Continuous infusion of piperacillin/tazobactam in septic critically ill patient...

The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients with microbiologically documented infections is currently unknown. We conducted a retrospective multicenter cohort study in 7 Portuguese intensive care units (ICU). We included 569 critically ill adult patients with a documented infection and treated with piperacillin/tazobactam admitted to one of the participatin...

Continuous Infusion of Piperacillin/Tazobactam in Septic Critically Ill Patient...

The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients with microbiologically documented infections is currently unknown. We conducted a retrospective multicenter cohort study in 7 Portuguese intensive care units (ICU). We included 569 critically ill adult patients with a documented infection and treated with piperacillin/tazobactam admitted to one of the participatin...

Prezygotic barriers to hybridization in marine broadcast spawners: Reproductive...

Sympatric assemblages of congeners with incomplete reproductive barriers offer the opportunity to study the roles that ecological and non-ecological factors play in reproductive isolation. While interspecific asynchrony in gamete release and gametic incompatibility are known prezygotic barriers to hybridization, the role of mating system variation has been emphasized in plants. Reproductive isolation between th...

Infecção pelo vírus Epstein Barr e hepatite

Introdução: A infecção pelo vírus Epstein Barr (VEB) tem uma prevalência elevada sendo mais de 90% da população mundial seropositiva. A maioria das infecções primárias pelo VEB é subclínica. As complicações agudas são raras mas potencialmente letais. Caso clínico: Criança do sexo feminino com nove anos admitida por febre elevada com 13 dias de evolução, dor abdominal e odinofagia. Os exames auxiliares de diagnó...

Highly sensitive C-reactive protein and male gender are independently related t...

Patients with metabolic syndrome are at high-risk for development of atherosclerosis and cardiovascular events. The objective of this study was to examine the major determinants of coronary disease severity, including those coronary risk factors associated with metabolic syndrome, during the early period after an acute coronary episode. We tested the hypothesis that inflammatory markers, especially highly sensi...

Recovery of quarries with autochthonous vegetal species at Arrábida Natural Park

To aid in the of environmental and landscape recovery quarries integrated in the Arrábida Natural Park (PNA) a contract involving official Portuguese entities was celebrated since 1998 to produce autochthonous plants. This contract was supported by the project “Valorisation of waste heat from Setúbal Power Plant in protected cultivation” that had the main goal to demonstrate the practical application of low ...