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Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...
Moniz, Sónia; Martinho, Olga; Pinto, Filipe; Sousa, Bárbara; Loureiro, Claúdia; Oliveira, Maria José; Moita, Luis Ferreira; Honavar, MrinaliniThe gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...
Protein Kinase WNK2 has a Tumour Suppressor Role in Gliomas
Moniz, Sonia; Martinho, Olga; Pinto, Filipe; Reis, Rui Manuel; Jordan, PeterMalignant glioblastoma is the most common and lethal adult brain tumour type. Recently, the promoter region of the protein kinaseWNK2 gene was found to be hypermethylated in 29 of 31 infiltrative gliomas and about 5 of 7 meningiomas. We have previously described that theexperimental depletion of WNK2 expression decreases RhoA activity whilst leading to increased Rac1 activity. RhoA/Rac1 activities are important...
Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator ...
Mendes, Ana Isabel; Matos, Paulo; Moniz, Sónia; Luz, Simão; Amaral, Margarida D.; Farinha, Carlos M.; Jordan, PeterMembers of the WNK (with-no-lysine [K]) subfamily of protein kinases regulate various ion channels involved in sodium, potassium, and chloride homeostasis by either inducing their phosphorylation or regulating the number of channel proteins expressed at the cell surface. Here, we describe findings demonstrating that the cell surface expression of the cystic fibrosis transmembrane conductance regulator (CFTR) is...
Functional characterisation of the novel WNK2 protein kinase
Moniz, Sónia Cristina da Rocha Pereira, 1973-Tese de doutoramento em Bioquímica (Genética Molecular), apresentada à Universidade de Lisboa através da Faculdade de Ciências, 2008 ; Segundo os dados da Organização Mundial de Saúde, o cancro é ainda uma das principais causas de morte em todo o mundo. No entanto, o conhecimento adquirido sobre as causas e os mecanismos envolvidos no desenvolvimento e progressão tumorais teve muito impacto na prevenção, detec...
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