Encontrados 5 documentos, a visualizar página 1 de 1
Anti-leishmanial and structure-activity relationship of ring substituted 3-phen...
Burguete,Asunción; Estevez,Yannick; Castillo,Denis; González,Germán; Villar,Raquel; Solano,Beatriz; Vicente,Esther; Silanes,Silvia Pérez; Aldana,IgnacioA series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships demonstrated the importance of a radical methoxy at position R3', R4' and R5'. (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3...
An easy and direct method for the synthesis of 1,2,4-triazole derivatives throu...
Rivera,Gildardo; Bocanegra-Garcia,Virgilio; Moreno,Antonio; Galiano,Silvia; Pérez,Silvia; Aldana,Ignacio; Monge,AntonioWe have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synth...
4º Simpósio sobre a Margem ibérica Atlântica
Monge, António; Barros, Pedro; Queiroz, Paula; Dias, J.; Rocha, Leonor; Leewaarden, W.In the southern coast of Algarve, eastward of Quarteira, some coastal segments have been subject to a last evolution, characterised by an accelerated shoreline retreat.
New antagonist agents of neuropeptide y receptors
Aldana,Ignacio; Rivero,Isabel; Rivero,Argimiro; Huenchuñir,Patricio; Frigola,Carmen; Alonso,Maria Luisa; Monge,Antonio; Caignard,D. H.; Renard,P.In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity. We report the synthesis and preliminary evaluation of some hydrazide derivatives as antagonists of rNPY.
Research and training in medicinal chemistry in south and central american coun...
Monge,AntonioWith the proposal to search for universal cooperation in the field of Medicinal Chemistry, the IUPAC group has elaborated a line of work divided into two phases: a- An Awareness of the true situation of Medicinal Chemistry in the different geographic areas of the world; b- A proposal of actions as to achieve more effective cooperation. This first report presents and discusses the actual situation in South and C...
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