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Clinical and genetic factors predicting response to therapy in patients with Cr...
Cravo, Marília; Ferreira, Paula; Sousa, Patrícia; Moura-Santos, Paula; Velho, Sónia; Tavares, Lurdes; Deus, João Ramos; Ministro, PaulaAim - To identify clinical and/or genetic predictors of response to several therapies in Crohn’s disease (CD) patients. Methods - We included 242 patients with CD (133 females) aged (mean ± standard deviation) 39 ± 12 years and a disease duration of 12 ± 8 years. The single-nucleotide polymorphisms (SNPs) studied were ABCB1 C3435T and G2677T/A, IL23R G1142A, C2370A, and G9T, CASP9 C93T, Fas G670A and LgC844T, a...
Acute necrosis of oesophagus.
Araújo, Ricardo; Castanheira, António; Machado, Joana; Ramalho, Ana; Cancela, Eugénia; Ministro, Paula; Silva, AméricoAcute esophageal necrosis is a very rare pathological entity, first described in 1990 by Goldenberg. The authors report the case of a patient of 79 years of age with this disease. The etiology of this type of esophageal injury is not yet well defined and has a reported mortality between 33 and 50% . We present this case by the rarity of the disease and the exuberance of endoscopic images in demonstration of thi...
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