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Individual common variants exert weak effects on the risk for autism spectrum d...

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stage...

A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ...

Functional impact of global rare copy number variation in autism spectrum disor...

The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability. Although ASDs are known to be highly heritable ( approximately 90%), the underlying ge...

Physics at CPLEAR

LEAR offered unique opportunities to study the symmetries which exist between matter and antimatter. At variance with other approaches at this facility, CPLEAR was an experiment devoted to the study of , and symmetries in the neutral-kaon system. A variety of measurements allowed us to determine with high precision the parameters which describe the time evolution of the neutral kaons and their antiparticles, in...

Measurement of the energy dependence of the form factor f+ in K0e3 decay

Neutral-kaon decays to [pi]e[nu] were analysed to determine the q2 dependence of the K0e3 electroweak form factor f+. Based on 365 612 events, this form factor was found to have a linear dependence on q2 with a slope [lambda]+=0.0245±0.0012stat±0.0022syst. ; http://www.sciencedirect.com/science/article/B6TVN-414F7YB-Y/1/f9d5dd66c27d4f9264d1cec6fac93c68

Tests of the Equivalence Principle with neutral kaons

We test the Principle of Equivalence for particles and antiparticles, using CPLEAR data on tagged K0 and decays into [pi]+[pi]-. For the first time, we search for possible annual, monthly and diurnal modulations of the observables [eta]+- and [phi]+-, that could be correlated with variations in astrophysical potentials. Within the accuracy of CPLEAR, the measured values of [eta]+- and [phi]+- are found not to b...

First direct observation of time-reversal non-invariance in the neutral-kaon sy...

We report on the first observation of time-reversal symmetry violation through a comparison of the probabilities of transforming into K0 and K0 into as a function of the neutral-kaon eigentime t. The comparison is based on the analysis of the neutral-kaon semileptonic decays recorded in the CPLEAR experiment. There, the strangeness of the neutral kaon at time t=0 was tagged by the kaon charge in the reaction at...

An EPR experiment testing the non-separability of the wave function

The EPR-type strangeness correlation in the K0 system produced in the reaction at rest has been tested using the CPLEAR detector. The strangeness was tagged via strong interaction with absorbers away from the creation point. The results are consistent with the QM non-separability of the wave function and exclude a spontaneous wave-function factorisation at creation (CL >99.99%). ; http://www.sciencedirect.co...

Mycotoxins in grain

Mycotoxin in grain