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Special Issue "Fluid Flow, Energy Transfer and Design"
Miguel, A. F.; Rocha, Luiz; Oechsner, AndreasFluid flow, thermodynamics and heat/mass transfer are central pillars of science and technology. They have been central to the development of our civilization because we use them to understand natural-world phenomena but also to move forward through incremental improvements in technology.
Patterns in estuarine macrofauna body size distributions: The role of habitat a...
Dolbeth, Marina; Raffaelli, Dave; Pardal, Miguel A.Schwinghamer's (1981) habitat architecture hypothesis for body mass spectra in marine sediments predicts a single macrofauna mode in response to the bulk nature of the sediment. This proposition was examined for intertidal macrofauna from a well-studied estuarine system, using kernel density estimation to define modality and the locations of peaks and troughs. Three sedimentary environments and habitats were ex...
Ophthalmic adverse drug reactions to systemic drugs: a systematic review
Miguel, A; Henriques, F; Azevedo, LF; Pereira, ACPURPOSE: To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization or assessment (namely drugs with original studies characterizing specific ophthalmic ADRs but without causality assessment nor without meta-analysis). METHODS: S...
Dendritic design as an archetype for growth patterns in Nature: fractal and con...
Miguel, A. F.The occurrence of configuration (design, shape, structure, rhythm) is a universal phenomenon that occurs in every flow system. Dendritic configuration (or tree-shaped configurations) is ubiquitous in nature and likely to arise in both animate and inanimate flow systems (e.g., lungs and river basins). Why is it so important? Is there a principle from which this configuration can be deduced? In this review paper...
Diffusion of levodopa in aqueous solutions of hydrochloric acid at 25 °C
Barros, Marisa C. F.; Ribeiro, Ana C. F.; Esteso, Miguel A.; Lobo, Victor M. M.; Leaist, Derek G.Ternary mutual diffusion coefficients (D11, D22, D12 and D21) measured by the Taylor dispersion method are reported for aqueous solutions of {levodopa (l-dopa) + HCl} solutions at 25 °C and HCl concentrations up to 0.100 mol · dm−3. The coupled diffusion of l-dopa (1) and HCl (2) is significant, as indicated by large negative cross-diffusion coefficients. D21, for example, reaches values that are larger than D1...
Fluid Flow in a Porous Tree-Shaped Network
Miguel, A. F.Tree-shaped flow networks connect one point to an infinity of points and are everywhere in Nature. These networks often own minimal flow resistance and vessel sizes obey to scaling power-laws. In this paper presents a model for fluid flow through a tree-shaped network with porous tubes. Hagen–Poiseuille flow is assumed for tubes and Darcy flow for the porous wall.
Accessing the Influence of Hess-Murray Law on Suspension Flow through Ramified ...
Serrenho, Ana; Miguel, A. F.The present study focuses on fluid flow and particle transport in symmetric T-shaped structures formed by tubes with circular and square cross-section. The performances of optimized structures (i.e., structures designed based on constructal allometric laws for minimum flow resistance) and not optimized structures were studied. Flow resistance and particle penetration efficiency were studied both for laminar and...
Effects of local and large-scale climate patterns on estuarine resident fishes:...
Nyitrai, Daniel; Martinho, Filipe; Dolbeth, Marina; Rito, João; Pardal, Miguel A.Large-scale and local climate patterns are known to influence several aspects of the life cycle of marine fish. In this paper, we used a 9-year database (2003e2011) to analyse the populations of two estuarine resident fishes, Pomatoschistus microps and Pomatoschistus minutus, in order to determine their relationships with varying environmental stressors operating over local and large scales. This study was perf...
From antimicrobial to anticancer peptides. a review
Gaspar, Diana; Veiga, A. Salomé; Castanho, Miguel A. R. B.Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Although AMPs have been essentially studied and developed as potential alternatives for fighting infectious diseases, their use as anticancer peptides (ACPs) in cancer therapy either alone or in combination with other conventional drugs has been regarded as a therapeutic strategy to explore. As human cancer remains ...
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
Vigant, Frederic; Lee, Jihye; Hollmann, Axel; Tanner, Lukas B.; Ataman, Zeynep Akyol; Yun, Tatyana; Shui, Guanghou; Aguilar, Hector C.; Zhang, Dong© 2013 Vigant et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 mM), and was...
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