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Fish scales patterning guiding hASC growth
Silva, Joana M.; Afonso, David Losa de Areia; Silva, Tiago H.; Volpato, F.; Motta, A.; Marques, A. P.; Mano, J. F.; Reis, R. L.; Migliaresi, C.Marine organisms and materials exhibit interesting properties for their use in biomedical applications, following biomimetic approaches [1,2]. For instance, the white seabass (Lates Calcarifer) scales exhibit a very interesting pattern, which inspire their use as a guiding platform for cellular growth, in a tissue regeneration approach. Moreover, fish scales are composed of hydroxyapatite and type I collagen fi...
Novel genipin cross-linked chitosan-silk fibroin sponges for cartilage engineer...
Silva, S. S.; Motta, A.; Rodrigues, Márcia T.; Pinheiro, A. F. M.; Gomes, Manuela E.; Mano, J. F.; Reis, R. L.; Migliaresi, C.The positive interaction of materials with tissues is an important step in regenerative medicine strategies. Hydrogels that are obtained from polysaccharides and proteins are expected to mimic the natural cartilage environment and thus provide an optimum milleu for tissue growth and regeneration. In this work, novel hydrogels composed of blends of chitosan and Bombyx mori silk fibroin were cross-linked with gen...
Genipin modified silk fibroin nanometric-nets
Silva, S. S.; Maniglio, D.; Motta, A.; Mano, J. F.; Reis, R. L.; Migliaresi, C.Nanometric silk-fibroin nets were fabricated by electrospinning from regenerated Bombyx mori silk-fibroin (SF)/formic acid solutions with the addition of genipin (GE), 2, 15 and 24 h after the solution preparation. After spinning, the pure fibroin nanofibers were water soluble and needed a further stabilization process, whereas the reaction of fibroin with genipin resulted in water-insoluble fibroin nets due to...
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