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Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...
Fraga, Alexandra G.; Cruz, Andrea; Martins, Teresa G.; Torrado, Egídio; Saraiva, Margarida; Pereira, Daniela Maria Ramos; Meyers, Wayne M.Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...
Response to treatment in a prospective cohort of patients with large ulcerated ...
Fraga, Alexandra G.; Pedrosa, Jorge; Longatto Filho, Adhemar; Kibadi, Kapay; Boelaert, Marleen; Kayinua, Makanzu; Minuku, Jean-BedelBACKGROUND: The World Health Organization (WHO) advises treatment of Mycobacterium ulcerans disease, also called "Buruli ulcer" (BU), with a combination of the antibiotics rifampicin and streptomycin (R+S), whether followed by surgery or not. In endemic areas, a clinical case definition is recommended. We evaluated the effectiveness of this strategy in a series of patients with large ulcers of > or =10 cm in lo...
Fine-needle aspiration, an efficient sampling technique for bacteriological dia...
Eddyani, Miriam; Fraga, Alexandra G.; Schmitt, Fernando; Uwizeye, C??cile; Fissette, Krista; Johnson, Christian; Aguiar, Julia; Sopoh, GhislainInvasive punch or incisional skin biopsy specimens are currently employed for the bacteriological confirmation of the clinical diagnosis of Buruli ulcer (BU), a cutaneous infectious disease caused by Mycobacterium ulcerans. The efficacy of fine-needle aspirates (FNA) using fine-gauge needles (23G by 25 mm) for the laboratory confirmation of BU was compared with that of skin tissue fragments obtained in parallel...
First cultivation and characterization of mycobacterium ulcerans from the envir...
Portaels, Françoise; Meyers, Wayne M.; Ablordey, Anthony; Castro, António G.; Chemlal, Karim; Rijk, Pim de; Elsen, Pierre; Fissette, KristaBackground: Mycobacterium ulcerans disease, or Buruli ulcer (BU), is an indolent, necrotizing infection of skin, subcutaneous tissue and, occasionally, bones. It is the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. There is evidence that M. ulcerans is an environmental pathogen transmitted to humans from aquatic niches; however, well-characterized pure cultures of M. ulceran...
Infection with Mycobacterium ulcerans induces persistent inflammatory responses...
Oliveira, Martinha S.; Fraga, Alexandra G.; Torrado, Egídio; Castro, António G.; Pereira, João P.; Longatto Filho, Adhemar; Milanezi, FernandaBuruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or absent inflammation. However, here we show that in the mouse M. ulcerans induces persistent inflammatory responses with viru-lence- dependent patterns. Mycolactone-positive, cytotoxic strains are virulent for mice an...
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