Encontrados 7 documentos, a visualizar página 1 de 1
Diverse physical growth trajectories in institutionalized portuguese children b...
Martins, Carla; Belsky, Jay; Marques, Sofia; Baptista, Joana; Silva, Joana; Mesquita, Ana Raquel Marcelino; Castro, Filipa; Sousa, Nuno; Soares, IsabelThe authors would like to thank the students involved in the data collection and coding, and especially the children, caregivers, and other institutional staff who participated in the study. Funding from Fundação para a Ciência e Tecnologia. ; Objective: To identify and analyze diverse longitudinal trajectories of physical growth of institutionalized children and their relation to child, family, and institutio...
Why do only some institutionalized children become indiscriminately friendly? I...
Soares, Isabel; Belsky, Jay; Mesquita, Ana Raquel Marcelino; Osório, Ana Alexandra Caldas; Sampaio, AdrianaUncorrected proof ; Why do some institutionalized children develop indiscriminate behavior (IB) while others do not? Consid- ering children with Williams syndrome (WS) may provide an answer because IB has been observed routinely among individuals with this rare genetic neurodevelopmental dis- order. By conceiving WS as a natural genetic model that mimics the indiscriminate phenotype and, more impor- tantly, is...
Role of human umbilical cord mesenchymal progenitors conditioned media in neuro...
Salgado, A. J.; Fraga, J. S.; Mesquita, Ana Raquel Marcelino; Neves, N. M.; Reis, R. L.; Sousa, NunoIt has been recently reported that mesenchymal progenitor/stem cells isolated from the Wharton’s Jelly (WJ) of umbilical cords (UC) ameliorate the condition of animals suffering from central nervous system (CNS)-related conditions. However, little is known on the mechanisms that regulate these actions. Therefore, the objective of the present work was to determine how the conditioned media (CM) of a population o...
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M.; Mesquita, Ana Raquel Marcelino; Oliveira, M??rio; P??go, Jos?? M.; Cerqueira, Jo??o; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoDepression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood [assessed with the forced-swimming (FST) and sucrose consumption tests (SCT)], anxiety [elevated-plus maze (EPM) and novelty suppressed feeding (NSF) tests]...
Interleukin-10 : a key cytokine in depression?
Roque, Susana; Neves, Margarida Correia; Mesquita, Ana Raquel Marcelino; Palha, Joana Almeida; Sousa, NunoAn increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the...
IL-10 modulates depressive-like behavior
Mesquita, Ana Raquel Marcelino; Neves, Margarida Correia; Roque, Susana; Castro, António G.; Vieira, Paulo; Pedrosa, Jorge; Palha, Joana AlmeidaThe role of pro-inflammatory cytokines in psychiatric disorders has been the focus of great research attention in recent years. Para- doxically, the same is not true for anti-inflammatory cytokines. In the present study, we assessed the behavioral profile of animals with altered expression of the anti-inflammatory cytokine IL-10. We performed a battery of tests to assess anxiety, depressive-like and cognitive b...
An integrative biological assessment of the programming effects of glucocortico...
Mesquita, Ana Raquel MarcelinoTese de Doutoramento em Ciências da Saúde – Ciências Biológicas e Biomédicas ; Manipulation of corticosteroid milieu during perinatal period has received much attention due to its implications in pathology later in life. The experience of stressful/traumatic events in early childhood, which triggers the activation of the HPA axis and the permanent increase in corticosteroids levels during critical periods of d...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||