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New insights into the effects of caloric restriction on Saccharomyces cerevisia...

Tese de doutoramento em Ciências da Saúde especialidade de Ciências da Saúde ; The aging of the population is one of the major transformations being experienced by most developed countries over the last century. Although the increase in lifespan expectancy can be seen as a success story for public health policies and for socio-economic development, it also challenges the society to adapt and promote health and...

Caloric restriction or catalase inactivation extends yeast chronological lifesp...

The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric res...

Growth signaling promotes chronological aging in budding yeast by inducing supe...

Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth arrest of stationar...

Decomposição da folhada de Eucalyptus globulus em sistemas lóticos : papel dos ...