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New insights into the biosynthesis of the Mycobacterial Methylglucose Lipopolys...

Mycobacterium tuberculosis owes much of its pathogenicity to a thick hydrophobic envelope, rich in complex fatty acids (mycolic acids), that protects the cells from the host’s defenses and modulates the immune response. Mycobacteria are known to synthesize cytoplasmic polymethylated polysaccharides (PMPS) that modulate fatty acid synthesis and act as their carriers to the cell wall assembly. Two PMPS were ident...