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Genetic screening of Alzheimer's disease genes in Iberian and African samples y...

Guerreiro, Rita João; Baquero, Miquel; Blesa, Rafael; Boada, Mercè; Brás, José Miguel; Bullido, Maria. J.; Calado, Ana; Crook, Richard; Ferreira, Carla

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65years) Alzheimer’s disease (AD). We performed a screening for mutations in the coding regions of presenilins, as well as exons 16 and 17 of the APP gene in a total of 231 patients from the Iberian peninsular with a clinical diagnosis of early onset AD (mean age at onset of 52.9 years; range 31– 64). We found t...


Clinical behavior of Streptococcus pneumoniae meningoencephalitis

Bu-Coifiu Fanego,Raisa; Dorta-Contreras,Alberto J.; Padilla-Docal,Bárbara; O' Farril-Sanchez,Martha; Lopez-Hernandez,Isabel

OBJECTIVE: There was an increased number of cases of meningoencephalitis caused by Streptococcus pneumoniae, after the successful vaccination campaigns against Neisseria meningitidis and Haemophilus influenzae. This paper aims at describing the clinical characteristics, the laboratory findings, the complications, and the therapeutic management of these patients, who have been suffering from this disease since 1...

Data: 2009   |   Origem: OASIS br

Meningoencephalitis by Naegleria fowleri: epidemiological study in Anzoategui s...

Cermeño,Julman R.; Hernández,Isabel; El Yasin,Helal; Tinedo,Rubén; Sánchez,Raúl; Pérez,Gladys; Gravano,Rosalía; Ruiz,Aida

A case of primary amoebic meningoencephalitis produced by Naegleria fowleri was diagnosed in the Independencia county of Anzoategui State, Venezuela. This case motivated the realization of the present epidemiological study with the aim of identifying free-living amoebae in this area. Representative water samples were taken and physicochemical and microbiologic analyses were carried out. Trophozoites and cysts o...

Data: 2006   |   Origem: OASIS br

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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia