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Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein ...
Pinheiro, Hugo; Carvalho, Joana; Oliveira, Patrícia; Ferreira, Daniel; Teixeira Pinto, Marta; Osório, Hugo; Licastro, Danilo; Bordeira-Carriço, RenataDisruption of E-cadherin (CDH1 gene) expression, subcellular localization or function arises during initiation and progression of almost 90% of all epithelial carcinomas. Nevertheless, the mechanisms through which this occurs are largely unknown. Previous studies showed the importance of CDH1 intron 2 sequences for proper gene and protein expression, supporting these as E-cadherin cis-modulators. Through RACE a...
Data: 2012
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Origem: Repositório Científico do Instituto Nacional de Saúde
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