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Screening of Five Essential Oils for Identification of Potential Inhibitors of ...
Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, CarlosNuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
Assessment of strategies to increase chondrocyte viability in cryopreserved hum...
Rosa, Susana Carvalho; Gonçalves, Juliana; Judas, Fernando; Lopes, Celeste; Mendes, Alexandrina FerreiraObjective: Allogeneic cartilage is used to repair damaged areas of articular cartilage, requiring the presence of living chondrocytes. So far, no preservation method can effectively meet that purpose. Identification of more effective cryoprotective agents (CPAs) can contribute to this goal. The aim of this study was to determine whether the glycosylated hydroquinone, arbutin, alone or in combination with low co...
Screening of Five Essential Oils for Identification of Potential Inhibitors of ...
Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, CarlosNuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
Differential roles of hydrogen peroxide and superoxide in mediating IL-1-induce...
Mendes, Alexandrina Ferreira; Caramona, M. Margarida; Carvalho, A. Pato; Lopes, M. CelesteOur previous studies showed that reactive oxygen species (ROS) are required for the pro-inflammatory cytokine interleukin-1beta (IL-1) to induce the activity of the Nuclear transcription Factor-kappaB (NF-kappaB) and the expression of the inducible isoform of the nitric oxide synthase (iNOS) in bovine articular chondrocytes. This study aimed at elucidating the role of hydrogen peroxide (H2O2) and the superoxide...
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