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Chondrocyte Viability in Fresh and Frozen Large Human Osteochondral Allografts:...
Judas, F.; Rosa, S.; Teixeira, L.; Lopes, C.; Mendes, A. FerreiraChondrocyte survival is a major goal for the effective storage and clinical performance of human osteochondral allografts. The majority of animal and human cryopreservation studies conducted so far have been performed in small osteochondral cylinders. Using human tibial plateaus as a model for large osteochondral pieces, this work sought to evaluate the cryoprotective efficiency of glycerol and dimethylsulfoxid...
Hydrogen peroxide mediates interleukin-1ß-induced AP-1 activation in articular ...
Mendes, A. Ferreira; Caramona, M. M.; Carvalho, A. P.; Lopes, M. C.The pro-inflammatory cytokine interleukin-1ß (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. This study aimed at elucidating the role of ROS, particularly H2O2, in mediating IL-1-induced activation of the transcription factor activator protein-1 (AP-1) in primary cultures of articular chondrocytes. AP-...
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced b...
Mendes, A. Ferreira; Carvalho, A. Pato; Caramona, M. Margarida; Lopes, M. CelesteAIMS: In this work, we studied the mechanisms by which diphenyleneiodonium chloride (DPI) inhibits nitric oxide (NO) synthesis induced by the proinflammatory cytokine interleukin-1beta (IL-1) in bovine articular chondrocytes. To achieve this, we evaluated the ability of DPI to inhibit the expression and activity of the inducible isoform of the NO synthase (iNOS) induced by IL-1. We also studied the ability of D...
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