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Expression and function of the insulin receptor in normal and osteoarthritic hu...
Rosa, S. C.; Rufino, A. T.; Judas, F.; Tenreiro, C.; Lopes, M. C.; Mendes, A. F.Objective Chondrocytes respond to insulin, but the presence and role of the specific high affinity insulin receptor (InsR) has never been demonstrated. This study determined whether human chondrocytes express the InsR and compared its abundance and function in normal and osteoarthritis (OA) human chondrocytes. Design Cartilage sections were immunostained for detection of the InsR. Non-proliferating chondrocyt...
Utilização de máquina fotográfica digital (multi-burst) para aulas experimentai...
Corveloni,E.P. Moraes; Gomes,E.S.; Sampaio,A.R.; Mendes,A.F.; Costa,V.L.L.; Viscovini,R.C.Nesse trabalho foi utilizada uma máquina fotográfica digital, com a função multi-burst (fotos tiradas em sequência) para analisar o movimento de queda livre e com os dados obtidos calcular o valor da aceleração da gravidade local. Para avaliar o experimento, foi também calculado um valor teórico para aceleração da gravidade local. Comparado com o obtido experimentalmente, foi possível observar um desvio pequeno...
Nitric oxide synthase isoforms and NF-jB activity in normal and osteoarthritic ...
Rosa, Susana C.; Judas, F.; Lopes, M. C.; Mendes, A. F.To elucidate the role of endogenous inducible nitric oxide (NO) on the regulation of NF-jB activity in human chondrocytes, we evaluated (i) the pattern of expression of the neuronal (nNOS) and inducible (iNOS) NO synthase isoforms and the basal NF-jB activity in normal and osteoarthritic (OA) human chondrocytes, (ii) the role of cytokines and growth factors in modulating the protein levels of the two NOS isofor...
Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activati...
Castro-Caldas, M.; Mendes, A. F.; Carvalho, A. P.; Duarte, C. B.; Lopes, M. C.AIMS: Glucocorticoids (GCs) exert some of their anti-inflammatory actions by preventing the activation of the transcription factor nuclear factor (NF)-kappaB. The GC-dependent inhibition of NF-kappaB may occur at different levels, but the mechanisms involved are still incompletely understood. In this work, we investigated whether the synthetic GC, dexamethasone (Dex), modulates the activity of NF-kappaB in the ...
Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expre...
Castro-Caldas, M.; Mendes, A. F.; Duarte, C. B.; Lopes, M. C. F.AIMS: Annexin 1 (ANXA1), a member of the annexin family of calcium-binding and phospholipid-binding proteins, is a key mediator of the anti-inflammatory actions of steroid hormones. We have previously demonstrated that, in the human lymphoblastic CCRF-CEM cell line, both the synthetic glucocorticoid hormone, dexamethasone (Dex), and the estrogen hormone, 17beta-estradiol (E2beta), induce the synthesis of ANXA1,...
Drawing and use of auxiliary projection nets (the program STEGRAPH)
Mendes, A. F.; Kullberg, J. C.The development of an algorithm for the construction of auxiliary projection nets (conform, equivalent and orthographic), in the equatorial and polar versions, is presented. The algorithm for the drawing of the "IGAREA 220" counting net (ALYES & MENDES, 1972), is also presented. Those algorithms are the base of STEGRAPH program (vers. 2.0), for MS-DOS computers, which has other applications.
Contagem de pontos em projecção triangular A rede de contagem TRIREDE
Mendes, A. F.The TRIREDE triangular counting net is presented, as well as the algorithm for its calculation and the TRIREDE program, used to project points in a triangular net and the calculation of a density grid.
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