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Assimetria motora inicial e sintomas não motores na Doença de Parkinson

Environment and Health in Children Day Care Centres in Portugal - results from ...

Publicado em: Proceedings of CLIMA 2013 : 11th REHVA World Congress and the 8th International Conference on Indoor Air Quality, Ventilation and Energy Conservation in Buildings ; Prague 16th - 19th June, 2013, Paper ID 876.

Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)

Abstract INTRODUCTION: Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings. CASE REPORT: Male, 48 years old, with an aura that included complex...

Psiquiatria comunitária na equipa da Brandoa: realidade assistencial em Dezembr...

O Serviço de Psiquiatria do Hospital Prof. Doutor Fernando Fonseca, EPE (HFF) foi o primeiro serviço em Portugal com base no hospital geral a desenvolver um modelo integrado de cuidados de saúde mental na comunidade, orientado para as necessidades da população e apoiado em equipas multidisciplinares. Este modelo assenta na continuidade de cuidados pela mesma equipa, no seguimento assertivo dos doentes na comuni...

Death ideation in cancer patients: contributing factors

Advances in cancer research and therapy have improved prognosis and the quality of life of many patients. However, previous epidemiological studies in oncologic patients have shown an increased risk of suicide. Suicidal thoughts, relatively well known in those terminally ill, may be just as important for cancer patients who are survivors or are living with the disease. Nonetheless, there is a relative paucity o...

Expression and function of the insulin receptor in normal and osteoarthritic hu...

Objective Chondrocytes respond to insulin, but the presence and role of the specific high affinity insulin receptor (InsR) has never been demonstrated. This study determined whether human chondrocytes express the InsR and compared its abundance and function in normal and osteoarthritis (OA) human chondrocytes. Design Cartilage sections were immunostained for detection of the InsR. Non-proliferating chondrocyt...

Antagonistic Regulation of CFTR Cell Surface Expression by Protein Kinases WNK4...

Members of the WNK (with no lysine (K)) subfamily of protein kinases regulate various ion channels involved in sodium, potassium and chloride homeostasis by either inducing their phosphorylation or regulating the number of channel proteins expressed at the cell surface. Here, we describe that WNK4 promotes the cell surface expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in mammalian...

Uma variante do gene WNK4 está associada à osteoporose mas não à hipertensão na...

Germline mutations in the WNK4 gene originate Gordon syndrome or pseudohypoaldosteronism type II, a familial form of hypertension with hyperkalemia and hypercalciuria. The WNK4 protein encodes a protein kinase involved in the regulation of various renal ion channels. In order to elucidate the contribution of WNK4 genetic variants to hypertension and/or osteoporosis, we analyzed 271 control individuals and a coh...

Um novo mecanismo molecular para a regulação do transportador de glicose GLUT1

Prémio de Investigação Básica ; One mechanism by which cells regulate the uptake of glucose is the number of glucose transporter proteins (GLUT) present at the plasma membrane. In insulin-responsive cells types, GLUT4 is released from intracellular storage vesicles through inactivation of the Rab GTPase activating protein TBC1D4, also known as AS160. Using protein biochemical techniques we analysed complex for...

Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking ...

Previously, the pleiotropic "master kinase" casein kinase 2 (CK2) was shown to interact with CFTR, the protein responsible for cystic fibrosis (CF). Moreover, CK2 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts, and Xenopus oocytes. CFTR possesses two CK2 phosphorylation sites (S422 and T1471), with unclear impact on its processing and trafficking. Here, we inves...