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Time course and mechanisms of left ventricular systolic and diastolic dysfuncti...
Correia-Pinto, J; Tiago Henriques-Coelho; Roncon-Albuquerque R, Jr.; Lourenço, AP; Melo-Rocha, G; Vasques-Nóvoa, F; Gillbert, TCAlthough pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular changes, Wistar rats were studied 4 and 6 weeks after subcutaneous injection of monocrotaline (MCT) 60 mg/kg (MCT...
Data: 2009
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Origem: Repositório Aberto da Universidade do Porto
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