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Study of lipid alterations related with Alzheimer disease
Melo, Tânia Sofia Rodrigues deAlzheimer disease is characterized by defects in the signaling mediated by acetylcholine. Tacrine was used as acetylcholinesterase (AChE) inhibitor approved for the treatment of Alzheimer’s disease. However, tacrine treatment has some toxicological effects associated with mitochondrial dysfunction, ROS generation and lipid peroxidation. Deregulation in sphingolipid metabolism is also associated with establishme...
Data: 2011
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Origem: RIA - Repositório Institucional da Universidade de Aveiro
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