Encontrados 8 documentos, a visualizar página 1 de 1
Thyroid Carcinoma in Children and Young Adults: Retrospective Review of 19 Cases
Saraiva, Joana; Departamento de Endocrinologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Introduction: Thyroid carcinoma is rare in children and young adults. Most of management guidelines are based in data from adult population. Several controversies remain regarding the aggressiveness of clinical presentation and therapeutic approach.Objective: To evaluate all differentiated thyroid carcinoma patients with less than 20 years-old at presentation reflecting the experience of our unit in relation to...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Porquê ajudar se nada tenho a ganhar? : a influência da empatia nos comportamen...
Melo, Miguel André Guedes deMestrado em Psicologia Socal e das Organizações ; Muitos dos estudos realizados acerca de bullying são centrados nos papéis mais salientes tais como a vítima/s e o agressor/s, ignorando largamente o papel representado pela grande maioria presente nestas situações: o bystander. Relativamente a este papel, sobretudo no que respeita ao bystander defensor, há que compreender como pode este ser influenciado pela em...
Implementation and development of a system for the fabrication of Bragg grating...
Melo, Miguel Alexandre Ramos deTese de mestrado. Engenharia Electrotécnica e de Computadores. 2006. Faculdade de Engenharia. Universidade do Porto, Faculdade de Ciências
Diversidade genética nos principais grupos populacionais em Angola- Aplicação f...
Melo, Miguel ManuelCiências Médicas ; Medical Sciences
Diabetic nephropathy: glomerular filtration rate and estimated creatinine clear...
Guimarães, Joana; Bastos, Margarida; Melo, Miguel; Carvalheiro, ManuelaTo assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR).We analysed the GFR measure by Tc99m-DTPA method and the estimated by the Cockroft Gault formula, in 21 subjects with type 1 or type 2 diabetes.There was a strong positive correlation between the two me...
Autoimmune thyroiditis.
Melo, MiguelThe term autoimmune thyroiditis encompasses a group of high prevalence thyroid disorders, which have been classified in different ways throughout the years. In this article some aspects related to its classification, epidemiology, susceptibility factors, pathogenesis, histology, diagnosis and treatment are reviewed. Some comments on the similar pathogenesis of Graves' disease are also made. ; The term autoimmu...
Friedreich ataxia and diabetes mellitus--family study.
Melo, Miguel; Serviço de Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.; Fagulha, Ana; Barros, LuisaFriedreich's ataxia (FA) is one of the genetic syndromes sometimes associated with diabetes and the most common hereditary ataxia. It is a autosomal recessive neurodegenerative disease, caused by a mutation in the FRDA gene, which originates decreased expression of frataxin, a mitochondrial protein involved in iron metabolism. The disorder is usually manifest in childhood and is characterised by ataxia, dysarth...
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